THE COMBINED TREATMENT WITH CHEMOTHERAPEUTIC AGENTS AND THE DUALSTERIC MUSCARINIC AGONIST IPER-8-NAPHTHALIMIDE AFFECTS DRUG RESISTANCE IN GLIOBLASTOMA STEM CELLS

Background: Glioblastoma multiforme (GBM) is characterized by heterogeneous cell populations.Among these, the Glioblastoma Stem Cells (GSCs) fraction shares some similarities with Neural Stem Cells.GSCs exhibit enhanced resistance to conventional chemotherapy drugs.Our previous studies demonstrated that the activation of M2 muscarinic acetylcholine

Introduction and Aim: Uncontrolled incremental trend of population growth is the basic problem in developing countries.Establishing family planning programs at an extensive level in these countries increases economical, social, and cultural advantages and decreases maternal and fetal mortality.One of the methods of implementing these programs is co

Accurate extraction of polarization resistance is crucial in the application of proton exchange membrane fuel cells.It is generally assumed that the steady-state resistance obtained from the polarization curve model is equivalent to the AC impedance obtained from the electrochemical impedance spectroscopy (EIS) when the frequency approaches zero.Ho

Daniel O Claassen, Scott J KutscherDepartment of Neurology, Vanderbilt University, Nashville, TN, USAAbstract: Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life.These disturbances manifest in a variety of ways; for instance, insomnia, sl

Abstract An early childhood skull deformity can have long-term health and aesthetic consequences for the growing toddler.Individual helmet therapy aims at a healthy growth of the skull shape, although not every helmet shape guarantees an optimal result.To ensure an optimal fit, a scanning procedure based on a hand-held surface scanner was evaluated